3-Amino-1-Boc-nipecotic acid

3-Amino-1-Boc-nipecotic acid - Names and Identifiers

Name	1-Boc-3-Aminopiperidine-3-carboxylic acid
Synonyms	3-Amino-1-Boc-nipecotic acid 5-hydroxypyridine-3-carbonitrile 1-Boc-3-Aminopiperidine-3-carboxylic acid 1-Boc-3-aMino-3-piperidinecarboxylic acid N-BOC-3,3-AMINO-PIPERIDINYLCARBOXYLIC ACID 1-N-BOC-3-AMINO-PIPERIDINE-3-CARBOXYLIC ACID 3-AMINO-1-(TERT-BUTOXYCARBONYL)PIPERIDINE-3-CARBOXYLIC ACID 3-AMINO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-Amino-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid 3-Amino-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester
CAS	368866-17-5
InChI	InChI=1/C6H4N2O/c7-2-5-1-6(9)4-8-3-5/h1,3-4,9H

3-Amino-1-Boc-nipecotic acid - Physico-chemical Properties

Molecular Formula	C11H20N2O4
Molar Mass	244.29
Density	1.203±0.06 g/cm3(Predicted)
Boling Point	380.1±42.0 °C(Predicted)
Flash Point	192.53°C
Vapor Presure	0mmHg at 25°C
pKa	2.26±0.20(Predicted)
Storage Condition	2-8°C(protect from light)
Refractive Index	1.595

3-Amino-1-Boc-nipecotic acid - Introduction

Acid (also known as Boc-APP acid) is an organic compound. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: A white crystalline solid.
-Molecular formula: C13H22N2O4
-Molecular weight: 270.33g/mol
-Melting point: about 128 degrees Celsius
-Solubility: Soluble in chloroform, dichloromethane and dimethyl sulfoxide, insoluble in water.

Use:
-the acid is often used as a starting material and intermediate in organic synthesis.
-It can be used to synthesize drugs, pesticides and other biologically active compounds.

Preparation Method:
-tert-acid can be synthesized by the following methods: First, 1-piperidinecarboxylic acid and tert-butyl dichloroformamide (Boc-Cl) are reacted to obtain 1-Boc-3-tert-butyl piperidine. 1-Boc-3-tert-butylpiperidine is then reacted with bromoacetic acid to produce 1-Boc-3-aminopiperidine-3-acetic acid. Finally, acid is obtained by hydrolytic esterification.

Safety Information:
-the acid is relatively safe under normal operation.
-Avoid contact with strong oxidants during use.
-Wear gloves and laboratory coats during operation, and ensure good ventilation.
-In case of accidental use or contact with skin or eyes, rinse with plenty of water and seek medical help.

Last Update：2024-04-09 21:01:54